In this study we focus on anti-Jo-1 (histidyl-tRNA synthetase). This autoantibody is associated with inflammatory muscle diseases and interstitial lung diseases (ILD). We retrospectively identified a cohort of patients tested for the panel of anti-ENA autoantibodies in our hospital.

We describe the clinical characteristics of our patients with anti-Jo-1 antibody disease, more than half of whom are AA reflecting the demographics of our medical center. We identified 15 patients with Jo-1 positive antibodies who were seen in our …

Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.(4,5).

2007年4月12日 · The presence of a positive ANA and anti-jo antibody test is very suggestive of polymyositis. However blood tests, no matter how positive, do not make the diagnosis of an autoimmune disease.

Anti-Jo1 is an anti-nuclear antibody. [1] [2] Anti-Jo1 has been associated with inflammatory myopathies such as polymyositis, dermatomyositis and antisynthetase syndrome. [3] [4] It has histidine-tRNA ligase as a target.

Anti-Jo-1 Ab (RDL), or Anti-Histidyl-tRNA Synthetase Antibody, is a pivotal serological marker extensively used in the diagnosis and management of autoimmune disorders, particularly Idiopathic Inflammatory Myopathies (IIM), including Polymyositis (PM) and Dermatomyositis (DM).

Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. (4,5).

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine …

Anti-Jo-1 antibody is most common antisynthetase antibody. Others include PL-7 and PL-12. Five additional antisynthetase antibodies have been identified so far, but there are much more rare and their implications are not well understood yet.

Anti-synthetase syndrome is an autoimmune condition, characterized by antibodies directed against an aminoacycl transfer RNA synthetase along with clinical features that can include interstitial lung disease, myositis, Raynaud’s phenomenon, and arthritis.