2021年6月22日 · Phospholipidosis depends on the physicochemical properties of drugs and does not reflect specific target-based activities—rather, it may be considered a toxic confound in …

Thus, despite their diverse chemotypes, a single mechanism of action may explain cellular antiviral activity of these drugs. Phospholipidosis disrupts lysosomal lipid catabolism and …

2006年10月9日 · Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of …

2020年3月16日 · Drug-induced phospholipidosis is a lysosomal storage disorder caused by accumulation of phospholipids. Here we summarize biomarkers and screening methods.

Drug-induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the accumulation of phospholipids within the lysosome. This adverse drug effect can occur in …

2019年12月18日 · Drug-induced phospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of phospholipids. Its cellular mechanism is still not well understood, …

Phospholipidosis induced by drugs with a cationic amphiphilic structure is a generalized condition in humans and animals that is characterized by an intracellular accumulation of phospholipids …

2009年12月14日 · Drug-induced phospholipidosis (PL) is an excessive accumulation of phospholipids and drug in lysosomes. Phospholipidosis signals a change in cell membrane …

2024年3月7日 · Drug-induced phospholipidosis (DIPL) can affect any cell or organ in the body. Clinical signs and symptoms of DIPL are non-specific. A principal histological feature of DIPL …

Phospholipidosis, the excessive accumulation of phospholipids within lysosomes, is a pathological response observed following exposure to many drugs across multiple therapeutic groups. A …