Thiophene is a heterocyclic compound with the formula C 4 H 4 S. Consisting of a planar five-membered ring, it is aromatic as indicated by its extensive substitution reactions. It is a colorless liquid with a benzene -like odor.

Thiophene is a naturally occurring substance found in coal tar and petroleum. It is also produced industrially for use as an organic synthesis reagent and may be released to the environment through a variety of waste streams.

Thiophene, the simplest sulfur-containing aromatic compound, with molecular formula C4H4S, which closely resembles benzene in its chemical and physical properties. It occurs with benzene in coal tar, from which source it was first isolated in 1883.

Thiophene being an electron-rich heterocycle is directly chlorinated with chlorine gas either in acetic acid or carbon tetrachloride yielding a mixture of polychlorinated products. Chlorination of thiophene with sulfuryl chloride gives a mixture of 2-chloro- and 2,5-dichlorothiophenes.

Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in the US FDA drug approval of small drug molecules, with around 7 drug approvals over the last ...

Thiophene is a heterocyclic compound of particular interest in the field of organic chemistry. This cyclic molecule, sometimes referred to as thiofuran, consists of four carbon atoms and one sulfur atom in a ring structure.

Thiophene is a five-membered heterocyclic compound containing a sulphur (S) atom (Gramec et al., 2014). Natural thiophenes from plants are reported to be found in many Asteraceae, especially the genus Echinops, Eclipta, Pluchea, Artemisia, Tagetes, Porophyllum, Atractylodes, Atractylodes, and Xanthium (Ibrahim et al., 2016).