2024年2月15日 · Compare quinolones and fluoroquinolones (fluoroquinolones). View important safety information, ratings, user reviews, popularity and more.

Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. [1] . They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production. [2]

2022年3月28日 · Quinolones are a type of antibiotic used to help fight against various bacteria. Because of their inhibition of several different types of microorganisms, they are considered broad-spectrum antibiotics.

2023年5月22日 · Quinolones are bactericidal antibiotics that directly kill bacterial cells. They act on bacterial type II topoisomerases, DNA gyrase, and topoisomerase IV, inhibiting their function and converting them into toxic enzymes that produce permanent double-stranded breaks in the bacterial chromosome.

2002年2月1日 · Quinolones provide exceptional coverage against atypical pathogens when infection with these organisms is suspected in patients with community-acquired pneumonia.

Quinolones are molecules structurally derived from the heterobicyclic aromatic compound quinoline, the name of which originated from the oily substance obtained after the alkaline distillation of quinine (Gerhardt, 1842).

Quinolone antibiotics are a powerful group of medications used to treat various bacterial infections. They work by targeting the bacteria's ability to replicate and survive, making them effective against a wide range of infections. However, their use comes with potential side effects and growing concerns about antibiotic resistance.

Most quinolones have excellent oral bioavailability, with serum drug concentrations equivalent to intravenous administration. Quinolones have few adverse effects, most notably nausea, headache,...

Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments.

Quinolones act by converting their targets, gyrase and topoisomerase IV, into toxic enzymes that fragment the bacterial chromosome. This review describes the development of the quinolones as antibacterials, the structure and function of gyrase and topoisomerase IV, and the mechanistic basis for quinolone action against their enzyme targets.