Two megakaryocytes in bone marrow, marked with arrows. A megakaryocyte (from mega- 'large' karyo- ' cell nucleus ' and -cyte ' cell ') is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting.

2023年10月30日 · Megakaryocytes are a special type of bone marrow cells that give rise to thrombocytes (platelets). These cells are large and measure about 50–150 µm in diameter …

2019年5月2日 · Megakaryocytes are large (50–100 μm) cells that are quite rare—making up ≈0.05% of the cell population in human bone marrow. 5 After megakaryocytes are terminally differentiated, they undergo a complex maturation process that is required for platelet production.

Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday production and release of millions of platelets into the bloodstream. Since the discovery and cloning, in 1994, of their principal humoral factor, thrombopoietin, ...

2022年1月27日 · Megakaryocytes (MKs), the largest of the hematopoietic cells, are responsible for producing platelets by extending and depositing long proplatelet extensions into the bloodstream.

Megakaryocytes (MKs) are easily identified in bone marrow as large cells, 30 to 100 μm in diameter. They contain multiple nuclei, undergoing sequential rounds of endomitosis to acquire a genomic content averaging 16N (range 4–128N).

2023年9月7日 · Megakaryocytes are commonly known as large, polyploid, bone marrow resident cells that contribute to hemostasis through the production of platelets. Soon after their discovery in the 19th century, megakaryocytes were described in tissue locations other than the bone marrow, specifically in the lungs and the blood circulation.

Here we discuss the differentiation of HSCs into megakaryocytes, with emphasis on the key cytokine signaling pathways and hematopoietic transcription factors. Recent insight into these processes elucidates the molecular bases of numerous acquired …

2024年11月5日 · While the conventional platelet-generating megakaryocytes (MKs) are recently emerging as a unique type of immune cells, they primarily reside in bone marrow (BM) as well as in lung and spleen, and are not considered as a regular constitute of PB.

Megakaryocytes are highly specialized precursor cells that produce and release platelets into the circulation. Understanding mechanisms by which megakaryocytes develop and give rise to platelets has fascinated hematologists for more than a century.