2013年12月24日 · Macroautophagy is one type of autophagic process in which the substrates are sequestered within cytosolic double-membrane vesicles termed autophagosomes. The substrates of macroautophagy include...

Macroautophagy is an evolutionarily conserved catabolic process whose main role is to degrade intracellular cargo for the supply of metabolites and energy to the cells. It consists of various vesicle trafficking events, generally triggered by stress conditions such as starvation.

Macroautophagy relies on de novo formation of cytosolic double-membrane vesicles, autophagosomes, to sequester and transport cargo to the lysosome. Chaperone-mediated autophagy transports individual unfolded proteins directly across the lysosomal membrane.

In the selective autophagy is the autophagy of organelles; mitophagy, [36] lipophagy, [37] pexophagy, [38] chlorophagy, [39] ribophagy [40] and others. Macroautophagy is the main pathway, used primarily to eradicate damaged cell organelles or unused proteins. [41]

Macroautophagy is a catabolic process for the lysosomal degradation and recycling of cytoplasmic constituents which has been implicated in several pathologies, including cancer and neurodegeneration. In some instances, macroautophagy acts to suppress tumor formation and neural degeneration.

Macroautophagy (hereafter autophagy), or ‘self-eating’, is a conserved cellular pathway that controls protein and organelle degradation, and has essential roles in survival, development and homeostasis.

Macroautophagy (hereafter referred to as autophagy) is a catabolic process in which portions of the cytoplasm are sequestered within double- or multimembraned vesicles termed autophagosomes and then delivered to lysosomes for bulk degradation.

Depending on the delivery route of the cytoplasmic material to the lysosomal lumen, three different autophagic routes are known: 1) macroautophagy, or simply autophagy, 2) microautophagy (Fig. 1), and 3) chaperone-mediated autophagy.

2010年6月15日 · Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis.

Macroautophagy is a catabolic process where cellular contents, including proteins, lipids, and even entire organelles, are digested within lysosomes. The process of macroautophagy begins with the formation and elongation of isolation membranes.