Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and …

mTOR signaling intersects with Alzheimer's disease (AD) pathology in several aspects, suggesting its potential role as a contributor to disease progression. In general, findings …

The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation …

2023年10月2日 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR …

Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and …

2020年1月14日 · In this Review, we analyse the signalling landscape of the mTOR pathway, from the inputs that regulate mTOR activation to the downstream effectors that enact its pro-growth …

In the central nervous system, the mTOR signaling cascade is activated by nutrients, neurotrophic factors, and neurotransmitters that enhances protein (and possibly lipid) synthesis and …

2017年3月9日 · Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR …

2024年1月12日 · The mTOR signaling pathway, which is frequently activated in tumors, is crucial for tumor metabolism because it not only controls protein synthesis and gene transcription to …

In this review, we provide an overview of our current understanding of the mTOR pathway and its role in growth, metabolism, and disease.