On to the biology. Homology is the blanket term, both ortho- and paralogs are homologs. So, when in doubt use "homologs". However: Orthologs are homologous genes that are the result of a speciation event. Paralogs are homologous genes that are the result of a duplication event.

2022年10月14日 · I already knew beforehand that each chromosome has 2 copies, but today was the first time that I asked "but why are they similar"? The father and mother should be genetically non-identical, but somehow the maternal and paternal copies of chromosome 1 for example are similar actually, enough to warrant them being called homologs of each other.

$\begingroup$ This is the definition of homology that disturbed me. you say we must consider global similarity rather than local similarity. accordingly, we can't say these two proteins are homologs, because just about 60% of their lengths have significant (above 80%) similarity and the rest of their sequence is not similar. But actually, we ...

2012年5月12日 · Just adding my 5 cents, there is a recent database called metaphors:. MetaPhOrs is a public repository of phylogeny-based orthology and paralogy predictions that were computed using resources available in seven popular homology prediction services (PhylomeDB, EnsemblCompara, EggNOG, OrthoMCL, COG, Fungal Orthogroups, and TreeFam).

And I'm guessing that the 2nd definition is an extension of the first by comparing gene assortment in all the homologous chromosomes: It looks like it is primarily talking about the genes that are on each pair of homologous chromosome and how they (the genes) separate independently of each other (because they are on different homologs) in ...

2016年6月29日 · With iterations the PSSM keeps getting updated, thereby, making the BLAST more sensitive in finding homologs. How PSSM is constructed : If a position in the alignment is conserved (i.e same residue in many sequences), it receives a high score whereas a position with low conservation gets a low score.

2017年5月6日 · I've read that homologous chromosomes are composed of one maternal chromosome and one paternal chromosome. I want to confirm if this image is for one set of homologous chromosomes: They have th...

2020年4月25日 · Answer: *Yes , human somatic cells have 22 pairs of homologous chromosomes The human genome consists of 46 (2n*(22+1) ) chromosomes.

2016年6月1日 · In such cases, we will decrease the word size for smaller proteins to increase our chances of finding homologs. 1 This is a bit of a simplification. The rules for extending alignments are a more complex but it serves to illustrate the point.

2018年4月15日 · If the two homologs are A and B, mom's being A1, B1, C1 and dad's being A2, B2, C2 - The eight possible combinations are A1B1C1, A1B1C2, A1B2C1, A1B2C2, A2B1C1, A2B2C1, A2B1C2, A2B2C2. Hope this helps.