Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of …

重组肠激酶轻链; Enterokinase, light chain; Enteropeptidase; Enterokinase; Serine protease 7; ENTK; MGC133046; PRSS7; TMPRSS15; protease, serine, 7 (enterokin

Enterokinase is a protease of the intestinal brush border that specifically cleaves the acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates a cascade of proteolytic reactions leading to the activation of many pancreatic zymogens.

enterokinase, proteolytic enzyme (q.v.), secreted from the duodenal mucosa, that changes the inactive pancreatic secretion trypsinogen into trypsin, one of the enzymes that digest proteins. Enterokinase is believed to be produced by the glands of Brunner in …

重组肠激酶 (recombinant Enterokinase, rEK) 的分子质量通常为26.3ku, 具有3个糖基化位点, 其糖基化分子质量大约为43ku。Vozza等发现, rEK体外实验证明有全酶酶切特异性并且相较于天然肠激酶表现出对基因工程融合蛋白底物的酶切活性增强, 因而现多采用基因工程的方法 ...

Enterokinase is a glycoprotein and is now designated enteropeptidase (E.C.3.4.4.8.). It is present in the duodenal and jejunal mucosa. Pancreatic proteolytic enzymes are secreted as proenzymes. Enterokinase converts trypsinogen to trypsin in the duodenal lumen.

enterokinase is a mosaic protein with a complex evolutionary history. The amino acid sequence surrounding the amino terminus of the enterokinase light chain is ITPK-IVGG (hu-man) or VSPK-IVGG (bovine), suggesting that single-chain enterokinase is activated by an unidentified trypsin-like pro-tease that cleaves the indicated Lys-Ile bond ...

2022年11月14日 · Human enteropeptidase (hEP), also known as enterokinase, is an essential enzyme in food digestion and is localized at the brush border of the duodenal and jejunal mucosa 1,2,3.

1989年3月1日 · Enterokinase is an essential enzyme for normal mammalian digestion. The enzyme is the physiological activator of trypsinogen, and the trypsin produced activates other zymogens forming a mixture of proteolytic enzymes1.

2023年9月8日 · Enterokinase deficiency is an extremely rare autosomal recessive disorder that affects the small intestine's ability to digest and absorb proteins. The disease is caused by mutations in the enterokinase (also known as enteropeptidase) gene, which encodes for the enzyme that activates trypsinogen to trypsin.