Baculoviridae is a family of viruses. Arthropods, among the most studied being Lepidoptera, Hymenoptera and Diptera, serve as natural hosts. Currently, 85 species are placed in this family, assigned to four genera. [1][2][3] Baculoviruses are known to infect insects, with over 600 host species having been described.

Baculoviruses are pathogens that attack insects and other arthropods. Like some human viruses, they are usually extremely small (less than a thousandth of a millimeter across), and are composed primarily of double-stranded DNA that codes for genes needed for virus establishment and reproduction.

Despite the limited set of genes that baculoviruses share, they do provide insight into some of the major functions required of all baculoviruses such as a common virion structure, the necessity to infect gut cells, and the use of a novel polymerase for the expression of late genes.

The baculoviruses (family: Baculoviridae) are a group of large DNA viruses that infect insects. These viruses are well known for their utility and versatility as gene expression vectors, biological pesticides, and vectors for transduction of mammalian cells [1] – [3] .

2019年6月28日 · Baculoviruses, which belong to the family Baculoviridae, are a group of DNA viruses that infect insects. These viruses are very small, rod-shaped structures, composing of a protein...

Currently, baculoviruses are primarily used for recombinant protein production and vaccines. This review will also discuss methods to optimize baculoviruses protein production and mammalian cell entry, limitations and potential for gene therapy and personalized medicine.

Topics including taxonomy, genome replication, early and late gene transcription, the application of baculoviruses as insecticides, the molecular basis for the remarkable ability of these viruses to express genes at high levels, and the interrelationships of baculovirus and transposable elements.

In this review, we will address the most widespread technological applications of baculoviruses. We will begin by summarizing their natural cycle both in larvae and in cell culture and how it can be exploited.

Baculoviridae is a family of large, insect-specific viruses with circular dsDNA genomes ranging from 80 to 180 kbp (Table 1. Baculoviridae). Virions consist of enveloped, rod-shaped nucleocapsids and are embedded in distinctive occlusion bodies typically measuring 0.5–5 µm.

2014年7月10日 · In this review, we first describe the general properties and biology of baculoviruses and then focus on the baculovirus genes and mechanisms involved in the replication, spread and survival of baculoviruses within the context of their diversity, evolution and insect manipulation.