DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair, where it complexes with DNA ligase III.

2024年12月25日 · XRCC1 (X-Ray Repair Cross Complementing 1) is a Protein Coding gene. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Xeroderma Pigmentosum Group D. Among its related pathways are Base excision repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs).

XRCC1 is an HSP90 client protein that protects XRCC1 from proteasome-mediated degradation. Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal.

2021年11月22日 · We show that aberrant PARP1 activity suppresses transcriptional recovery during base excision repair by promoting excessive recruitment and activity of the ubiquitin protease USP3, which as a...

X-ray cross complementing group 1 protein (XRCC1) forms enzyme complexes optimized for single-strand break repair, but participates in other repair pathways as well. Available structural data for XRCC1 interactions is summarized and evaluated in terms of …

2023年12月4日 · A meta-analysis of XRCC1 single nucleotide polymorphism and susceptibility to gynecological malignancies. Zhang XQ, Li LZhang XQ, et al. Medicine (Baltimore), 2021 Dec 17. PMID 34918657; XRCC1 protects transcription from …

2019年9月1日 · XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs).

X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base excision repair and single strand break repair, and is also a participant in other repair pathways. It also serves as an important co-transporter for several other repair proteins, including aprataxin and …

XRCC1 is a prognostic marker in Liver hepatocellular carcinoma, Lung squamous cell carcinoma