Recombination is a pervasive process generating diversity in most viruses. It joins variants that arise independently within the same molecule, creating new opportunities for viruses to overcome selective pressures and to adapt to new environments and hosts.

2011年7月4日 · RNA viruses are able to undergo two forms of recombination: RNA recombination, which (in principle) can occur in any type of RNA virus, and reassortment, which is restricted to those viruses...

Recombination is a pervasive process generating diversity in most viruses. It joins variants that arise independently within the same molecule, creating new opportunities for viruses to overcome selective pressures and to adapt to new environments and hosts.

A recombinant virus may occur naturally or be produced by recombining pieces of DNA or RNA in a laboratory. This may be used to produce viral vaccines or gene therapy vectors. The term is also used to refer to naturally occurring recombination between virus genomes in a cell infected by more than one virus strain.

Explore how viral recombination shapes genetic diversity, influencing virus evolution and adaptation across RNA and DNA viruses.

Recombination in many DNA viruses is believed to be accomplished by cellular enzymatic activities. There are two general types of genetic DNA recombination in the cell: homologous recombination (general recombination) and nonhomologous recombination.

Similarly, viral recombination is a phenomenon that occurs when two viruses co-infect the same cell and interact during replication to generate progeny, the genomes of which contain genetic information obtained from both parental strains.

2018年7月6日 · Recombination between and within virus genomes is being increasingly recognized as a major driver of virus evolution. Virus evolution can lead to changes in virus pathogenesis and virus ecology.

2024年10月7日 · Viruses exhibit remarkable adaptability, largely due to the sophisticated recombination processes within their genomes. This genetic shuffling enables viruses to rapidly evolve, giving rise to new variants with potentially altered pathogenicity or transmissibility.

Viral recombination is a major evolutionary mechanism driving adaptation processes, such as the ability of host-switching. Understanding global patterns of recombination could help to identify underlying mechanisms and to evaluate the potential risks of rapid adaptation.