In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

Transcriptional regulation is a critical biological process that allows the cell or an organism to respond to a variety of intra- and extra-cellular signals, to define cell identity during development, to maintain it throughout its lifetime, and to coordinate cellular activity.

2023年8月31日 · Regulatory sequences are bound tightly and specifically by transcriptional regulators, proteins that can recognize DNA sequences and bind to them. The binding of such proteins to the DNA can regulate transcription by preventing or increasing transcription from a particular promoter.

The regulation of transcription by repressors as well as by activators considerably extends the range of mechanisms that control the expression of eukaryotic genes. One important role of repressors may be to inhibit the expression of tissue-specific genes in inappropriate cell types.

2019年8月28日 · Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have...

Regulation of transcription in eukaryotes is a result of the combined effects of structural properties (how DNA is "packaged") and the interactions of proteins called transcription factors....

Transcription, the critical initial stage in gene expression, is regulated delicately to maintain the cell status. Recent developments in the genomic approaches provided unparalleled coverage of the study of transcription.

We begin with a brief review of the basic features of human genes and the fundamentals of gene regulation. This leads to a discussion of cellular gene expression programs and the mechanisms involved in global regulation of transcription.

2024年1月19日 · We discuss findings of lncRNAs that elicit a function through either activation of their transcription, transcript elongation and processing or the lncRNA molecule itself. We also discuss...

2023年6月20日 · They are transcription factors (regulating the genes that determine the next developmental fate), and they have this same protein motif for their DNA binding domains. Some specific examples are the products of these genes: the pair-rule gene eve= even skipped; the segment polarity gene en= engrailed; the homeotic gene Antp= antennapedia; Figure ...