Toxic granulation refers to dark coarse granules found in granulocytes, particularly neutrophils, in patients with inflammatory conditions. [1] Along with Döhle bodies and toxic vacuolation, which are two other findings in the cytoplasm of granulocytes, toxic granulation is a peripheral blood film finding suggestive of an inflammatory process. [1]

Toxic granulation is a persistence of the deep blue-purple color of the primary granules of the neutrophil; they are azurophilic and appear most prominent in neutrophils and band forms, but are also present in myelocytes and metamyelocytes. These granules are thought to be due to abnormal, accelerated maturation and exit from the marrow space.

2023年10月17日 · Toxic granulation is a condition that affects the body's white blood cells, as there is the presence of granules in the cytoplasm of neutrophils. Neutrophils are a type of white blood cell commonly referred to as PMNs (polymorphonuclear leukocytes).

Toxic granulation refers to the presence of abnormal granules within neutrophils observed during a blood smear analysis. These abnormal white blood cell granules have a distinct appearance compared to normal neutrophil granules.

Toxic granulation is the accumulation of big, dark granules in segmented neutrophils (or, sometimes, in earlier neutrophil precursors). It is likely due to the demand placed on the marrow to get those neutrophils out in the circulation as soon as possible in order to fight the infection.

Toxic granulation is the presence of large purple or dark blue cytoplasmic granules (primary granules) in neutrophils, bands, and metamyelocytes. The granules are slightly larger, more numerous and have an increased staining density compared to normal neutrophil granules.

A common and important morphologic abnormality of neutrophils is so-called “toxic change“. Contrary to what has been written in many books, toxic change in neutrophils is not necessarily associated with “toxemia”.

2015年9月17日 · Toxic granulation in neutrophils is found in inflammatory states. The toxic granules are azurophilic, and may be found in the promyelocyte, metamyelocyte, band (shown here), and mature stages.

Toxic Granulation: 1-3 Dark blue-black peroxidase positive granules that appear in the cytoplasm of the neutrophil. Appear very similar to Alder-Reilly bodies found in Alder-Reilly anomaly but is commonly found with other features of toxicity.

Toxic vacuolation is associated with sepsis, particularly when accompanied by toxic granulation. [4] The finding is also associated with bacterial infection, [3] alcohol toxicity, liver failure, [4] and treatment with granulocyte colony-stimulating factor, a cytokine drug used to increase the absolute neutrophil count in patients with neutropenia. [5] [6]The formation of toxic vacuoles ...