Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, [1] aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin. Thromboplastin is found in brain, lung, and other tissues and especially in blood platelets.

A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions, thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in blood coagulation. Synonym …

2023年6月20日 · A partial thromboplastin time test measures how long it takes your blood to make a clot. It can tell you how much of certain clotting factors you have in your blood. And it can tell you if they’re working right.

Thromboplastins were originally tissue extracts obtained from different species and different organs containing tissue factor and phospholipid. Because of the potential hazard of viral and other infections from handling human brain, it should no …

2024年9月9日 · The partial thromboplastin time (PTT) test is a component of the diagnostic toolkit for evaluating blood coagulation disorders. Abnormalities in blood clotting can lead to significant health risks, including excessive bleeding or blood clot formation.

Thromboplastin is a substance that is upregulated and released from damaged brain tissue after moderate or severe Traumatic Brain Injury (TBI). It activates procoagulant factors, leading to blood clot formation and potentially increasing the risk of cerebral infarction.

2006年2月7日 · Tissue factor (TF), formerly known as thromboplastin, is the key initiator of the coagulation cascade; it binds factor VIIa resulting in activation of factor IX and factor X, ultimately leading to fibrin formation.

2024年9月20日 · Several tests of the coagulation system are available, including the prothrombin time (PT), activated partial thromboplastin time (aPTT), and others; these may be ordered in a variety of clinical settings. This topic reviews the principles and interpretation of coagulation tests that are routinely available for clinical use.

The protein on the surface of cells that is responsible for the initiation of blood clotting is known as tissue factor, or tissue thromboplastin. Tissue factor is found in many of the cells of the body but is particularly abundant in those of the brain, lungs, and placenta.

Thrombosis is a group of pathologic conditions in which the clotting cascade is triggered inside the lumen of a blood vessel, leading to the formation of a blood clot (known, in this case, as a “thrombus”) that can impede the flow of blood within a vessel.