Hyperammonemia is associated with chronic and acute liver injury. There is no promising therapeutic agent against ammonia-induced complications. Hence, finding therapeutic molecules with safe profile of administration has clinical value.

Taurine (2-aminoethylsulfonic acid) has many physiological and pharmacological functions in most tissues. It is abundantly maintained in the liver by both endogenous biosynthesis and exogenous transport, but is decreased in liver diseases.

2023年10月2日 · Form bile salts in the liver, which help with digestion. Bile acids are crucial to our metabolism because they’re responsible for breaking down the fatty acids in your intestines, like ...

2021年2月1日 · These data shows that taurine can accelerate ethanol metabolism, reduce the accumulation of ethanol in the liver and its damage effect, suggesting taurine has the potential for the treatment of alcoholic liver disease.

In an iron-overload murine model of oxidative stress, which mimics features of chronic liver diseases (such as alcoholic liver disease and chronic viral hepatitis), taurine has been shown to reduce the accumulation of ROS, thereby exhibiting strong anti-oxidant activity .

The study suggested that dietary amino acid taurine may ameliorate liver injury for chronic hepatitis patients. The effect of dietary amino acid taurine on the liver function of chronic hepatitis patients was investigated.

2023年2月28日 · Taurine may have protective effects against chronic and acute liver injury. Although promising, these potential benefits are less studied or are primarily supported by animal and...

Long-term feeding of taurine lowered plasma cholesterol and bile acids without significantly changing other metabolic parameters, but hardly affected these levels in the liver. Moreover, taurine upregulated Cyp7a1 levels, while downregulated phosphorylated ERK and Fgf21 levels in …

2024年12月11日 · Taurine boosts insulin sensitivity by enhancing the phosphorylation of insulin receptor substrates and Akt protein, improving liver insulin signaling. This supports better metabolism in cells, aiding recovery. Thus, taurine holds a key role in diabetes management by enhancing insulin sensitivity.

Taurine has been studied extensively for its potential in managing liver diseases like non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. Research suggests that taurine supplementation may help improve liver function and prevent liver damage in individuals with these conditions.