2024年11月19日 · Tablet defects or manufacturing defects of tablets are not acceptable. But often tablet defects embarrass tablet manufacturers or formulators to design a new tablet. This article outlines various remedies that resolve various tablet …

2023年7月21日 · Insufficient compression force results in weak bonding between the granules. Tablet formulations lack good binding properties. Poor granule flow leads to uneven distribution of the material. Remedies for Capping: Adjust the compression force to improve the bonding between the granules.

2021年8月14日 · In this article, we will discuss almost all possible defects which may occur during tablet compression operation and will also discuss the reasons for these problems and will discuss how to solve or troubleshoot these compression issues.

2024年1月11日 · Tablet defects are deficiencies that are usually encountered in tablet formulation. Depending on experience, machinery and excipient used, produced or compressed tablets can develop certain defect which may be immediately apparent …

2024年11月25日 · Below, we’ll discuss the most prevalent defects and how they affect tablet quality: 1. Capping and Lamination. Capping occurs when the upper or lower tablet surface separates from the main body, while lamination refers to the splitting of tablets into multiple layers. Causes: Inadequate moisture in granules. High compression force during tableting.

2024年7月15日 · Tablet processing problems can be due to problems in the formulation or in compression equipment, or both of them. Thus we can classify the problems into the following types: The Defects related to Tabletting Process. Capping: It is partial or complete separation of the top or bottom of tablet due air-entrapment in the granular material.

2020年9月18日 · Most of the defects in tablets occur in compression stage of tablets and these could be categorized as critical, major and minor defects on the basis of the severity of the defect.

2024年5月29日 · Tablet quality and efficacy are essential factors in pharmaceutical manufacturing. For high standards to be confirmed, it is important to understand the causes and remedies of all the problems that may arise during the production process. 1. Picking. 2. Sticking. 3. Capping. 4. Lamination. 5. Chipping. 6. Cracking. 7. Flashing. 8. Mottling. 9.

2021年8月7日 · Defects related to the tableting process: 1. Capping: It is partial or complete separation of the top or bottom of the tablet due to air-entrapment in the granular material. 2. Lamination: It is the separation of the tablet into two or more layers due to air-entrapment in the granular material. 3.

2024年3月5日 · The following are the 5 most common causes of tablet defects. 1. Inadequate Tablet Compression: Compression is one of the key steps of tablet manufacturing that compresses the powder into the tablet form. Inadequate compression can make the tablets too soft they can break easily during transport or during further steps like coating and ...