Swainsonine is an indolizidine alkaloid. It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. [1] . As a toxin in locoweed (likely its primary toxin [2]) it also is a significant cause of economic losses in livestock industries, particularly in North America.

Locoweed (also crazyweed and loco) is a common name in North America for any plant that produces swainsonine, an alkaloid harmful to livestock. Worldwide, swainsonine is produced by a small number of species, most of them in three genera of the flowering plant family Fabaceae: Oxytropis and Astragalus in North America, [1] and Swainsona in ...

2009年7月7日 · Swainsonine is an indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8. It has a role as an antineoplastic agent, an immunological adjuvant, an EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor and a plant metabolite.

Swainsonine is a synthetic salt form of a plant toxin derived from a plant called locoweed. It is a competitive inhibitor of Golgi α-mannosidase II and affects the structure of carbohydrates, which can inhibit metastasis and impact the function of lymphocytes.

Swainsonine is known for its immunomodulator potential, and it is found in several species of the Fabaceae and Convolvulaceae families [49]. Castanospermine is a related compound originally discovered in the seeds of Castanospermum austral [50] .

Swainsonine, an indolizidine alkaloid with immunomodulatory activity, has been found to be effective in inhibiting metastatic dissemination and growth of primary tumors of both murine and human origins.

2014年7月30日 · Swainsonine, an indolizidine alkaloid with significant physiological activity, is an α-mannosidase and mannosidase II inhibitor that alters glycoprotein processing and causes lysosomal storage disease. Swainsonine is present in a number of plant species worldwide and causes severe toxicosis in lives …

Swainsonine is an indolizidine alkaloid produced by certain species of the plants genera Astragalus, Oxytropis, and Swainsona. From: Clinical Biochemistry of Domestic Animals (Sixth Edition), 2008

Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture.

2017年11月28日 · Swainsonine (SW) is the principal toxic ingredient of locoweed plants that causes locoism characterized by a disorder of the nervous system. It has also received widespread attention in the medical field for its beneficial anticancer and antitumor activities.