Smallpox vaccine was inoculated by scratches into the superficial layers of the skin, with a wide variety of instruments used to achieve this. They ranged from simple needles to multi-pointed and multi-bladed spring-operated instruments specifically designed for the purpose. [137]

Smallpox inoculation was a simple procedure: a doctor removed pus from an active pustule of an infected person, and then inserted that pus into the skin of a non-infected person via a small incision. The insertion of the pus resulted in the inoculated person contracting smallpox.

Smallpox was highly infectious, with no known cure. It began as early as 1350 BCE, with cases being found in the study of Egyptian mummies. The ancient practice of variolation (named for smallpox, also known as variola or ‘la variole’) was widely used in Asia and some parts of Africa.

2019年4月25日 · Smallpox vaccination is based on a thousand-year old technique called inoculation, in which a small sample of infected matter is deliberately introduced into the body in order to prevent the full disease from developing.

Early in the 18 th century, variolation (referred to then as ‘inoculation’) was introduced to Britain and New England to protect people likely to be at risk of infection with smallpox. This triggered a number of important developments.

Inoculation with vaccinia virus is highly effective for the prevention of smallpox infection, but it is associated with several known side effects that range from mild and self-limited to severe and life-threatening.

Inoculation referred to the subcutaneous instillation of smallpox virus into nonimmune individuals. The inoculator usually used a lancet wet with fresh matter taken from a ripe pustule of some person who suffered from smallpox.

One of the most feared diseases in the eighteenth century was smallpox. A high percentage of those infected died; many who survived were blinded or badly disfigured. Inoculation against the disease had been introduced into Europe from the Middle East early in the century and subsequently conveyed to the American colonies.

2020年3月24日 · In the early decades of the eighteenth century, smallpox inoculation was introduced into northern Europe from the Middle East. The method consisted of grafting or ‘inoculating’ infected matter...

Before the First Smallpox Vaccine. Smallpox was first described in the year 910, and it would be almost 800 years of horrors before a vaccine was developed. 910. Measles and Smallpox Described Separately. Read more. 1000. Early Chinese Inoculation. Read more. 1625. Early Smallpox in North America. Read more. 1678.