2021年7月13日 · The molecules and compounds expressed by senescent cells (known as the senescent secretome) play important roles across the lifespan, including in embryonic development, childbirth, and wound healing.

The nucleus of senescent cells is characterized by senescence-associated heterochromatin foci (SAHF) and DNA segments with chromatin alterations reinforcing senescence (DNA-SCARS). [19] Senescent cells affect tumour suppression, wound healing and possibly embryonic/placental development and a pathological role in age-related diseases. [20]

2018年5月25日 · With aging, senescent cells accumulate in the bone microenvironment where they promote osteoclastogenesis and inhibit osteoblastogenesis. Senolytic therapy alleviates these effects by eliminating senescent cells, which in turn reduces bone resorption and either maintains (trabecular sites) or enhances (cortical sites) bone formation due to ...

2024年6月17日 · When cells become senescent, they can slow or halt the growth of cancer, blood-vessel-stiffening plaque, and other health problems. Senescence also may hinder the progression of pulmonary and cardiac fibrosis and liver cirrhosis.

2017年5月26日 · Cellular senescence is a state in which cells can no longer divide. Therefore, if cancer cells become senescent, their division and spread are hampered.

2 天之前 · Senescent cells. With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules. Cellular senescence is a cell state that occurs in response to diverse forms of stress and a hallmark of aging. As individuals age, senescent cells accumulate in many tissues and mediate ...

SenNet will provide publicly accessible atlases of senescent cells, the differences among them, and the molecules they secrete, using data collected from multiple human and model organism tissues.

21 小时之前 · Senescent cells exhibit permanent growth arrest and increased expression of cell cycle inhibitors like p16 INK4a and/or p21 CIP1, along with alterations in cellular structures and protein expression. Senescence is further characterized by the SASP factors, the presence of DNA damage foci, and the formation of SAHF.

2022年8月1日 · Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives secondary senescence and disrupts tissue homeostasis, resulting in loss of tissue repair and regeneration.

Senescence is cellular program that induces a stable growth arrest accompanied by distinct phenotypic alterations, including chromatin remodeling, metabolic reprogramming, increased autophagy, and the implementation of a complex proinflammatory secretome (Kuilman et al., 2010; Salama et al., 2014).