2023年7月10日 · Salicylate toxicity is a medical emergency. Intentional ingestion or accidental overdose can cause severe metabolic derangements making treatment difficult. Co-ingestion of other medications can further complicate management.

2021年10月1日 · Acid-base status can suggest salicylate toxicity, but cannot exclude it. Note also that patients with co-ingestion may not manifest with classic acid/base patterns (e.g., aspirin plus opioids may not lead to a respiratory alkalosis).

2020年11月3日 · Salicylates in acute overdose classically cause a respiratory alkalosis by stimulating the respiratory centres in the brain followed by a metabolic acidosis by uncoupling oxidative phosphorylation. The classic triad of mild toxicity is nausea, vomiting and tinnitus,

2023年11月13日 · This topic will discuss the clinical manifestation and evaluation of salicylate overdose and toxicity in children and adults. A rapid overview table to facilitate emergency management is provided ( table 1 ).

Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears, nausea, abdominal pain, and a fast breathing rate. [1] Early on, these may be subtle, while larger doses may result in …

Acute ingestion of > 150 mg/kg of salicylate can cause severe toxicity. Salicylate tablets may form bezoars, prolonging absorption and toxicity. Chronic toxicity can occur after several days or more of high therapeutic doses; it is common, often undiagnosed, and often more serious than acute toxicity. Chronic toxicity tends to occur in older ...

2024年2月19日 · This topic will discuss the management of salicylate overdose and toxicity in children and adults. A rapid overview table to facilitate emergency management is provided ( table 1 ). The clinical manifestations and evaluation of salicylate poisoning are discussed separately.

Salicylate Sources. Aspirin; Oil of Wintergreen Oil of Wintergreen is very concentrated - 5mL contains equivalent of 7.5g of aspirin. Pepto-Bismol; Wart removers; Maalox; Alka-Seltzer; Pathophysiology. Uncouples oxidative phosphorylation → increased metabolic rate and hyperthermia. As level rises, switches from hepatic to renal clearance (slower)

2020年6月24日 · This article highlights the risk factors for salicylate toxicity; reviews the pathophysiological effects; notes the hidden sources of salicylates, including foods, drugs, and topical ointments...

Salicylate toxicity is a complex problem that may develop with either acute or chronic exposure to salicylates. Salicylates are found in over-the-counter medications including aspirin, bismuth subsalicylate, effervescent antacids, ointments, liniments, and oil of wintergreen (methyl salicylate) and alternative medication products (e.g., willow ...