Radioprotective countermeasures are radioprotective agents that prevent and reduce IR injury or have therapeutic effects. Based on a good understanding of radiobiology, a number of protective agents have achieved positive results in early clinical trials.

Radioprotective agents have been investigated using various models including cells, animals, and recently humans. The data suggest that radioprotective agents working through a variety of mechanisms have the potential to decrease free radical damage produced by ionizing radiation.

Radioprotectors are agents required to protect biological system exposed to radiation, either naturally or through radiation leakage, and they protect normal cells from radiation injury in cancer patients undergoing radiotherapy.

There could be radioprotective effects resulting from the systemic (vasodilation, hypotension, hypoxia) and cellular (elevation of cAMP in sensitive cells) consequences of adenosine receptor activation .

Radioprotective agents provide significant protection against the harmful effects of radiation. The mode of radioprotective action mechanisms has been reviewed. Podophyllum hexandrum and its derived bioactive constituents have the potentials to become novel radioprotective agents.

Radioprotective agents such as Amifostine and Palifermin protect normal cells against side effects and injuries caused by ionizing radiation especially during radiotherapy.

2023年2月6日 · Radioprotective countermeasures are radioprotective agents that prevent and reduce IR injury or have therapeutic effects. Based on a good understanding of radiobiology, a...

2016年1月25日 · Radioprotectors are agents required to protect biological system exposed to radiation, either naturally or through radiation leakage, and they protect normal cells from radiation injury in cancer patients undergoing radiotherapy.

2018年10月1日 · Radioprotective mechanisms are multidimensional in nature, which ranges from radical scavenging to gene therapy. More than one mechanism and approach can be implemented to achieve optimal radiation protection.

3 天之前 · A novel approach developed by scientists, including Rice University chemist James Tour, could transform treatment for pancreatic cancer, one of the deadliest cancers with limited therapeutic options.Researchers have introduced a targeted nasal delivery method that repurposes WR-2721, generically known as amifostine — a radioprotective prodrug historically …