Damage to the retinal pigment epithelium (RPE) is considered to be a hallmark of AMD. There are several changes to the RPE and its surrounding microenvironment; however, some of these changes also occur over the course of normal ageing in the eye.

Our results indicate that the severity of retinal pigment epithelium and outer retina atrophy (RORA), indirectly quantified through the detection of SRI areas by commercial OCT algorithms, is correlated with central retinal dysfunction, as determined by visual acuity and fERG, supporting the combined use of structural exams and functional tests ...

2025年1月27日 · An extensive area of geographic, submacular pigment atrophy involves the entire posterior retina between the temporal retinal vascular arcades. The underlying choroidal vasculature is more prominent when the pigment epithelium is absent or atrophic.

Here we review the function of the retinal pigment epithelium and its relevance to the pathobiology, and discuss potential strategies for the treatment of retinopathies. In doing so, we provide new viewpoints outlining new ideas for the future study and treatment of retinopathies.

2017年6月12日 · Recognizing that photoreceptor atrophy can occur without retinal pigment epithelium (RPE) atrophy and that atrophy can undergo an evolution of different stages, 4 terms and histologic candidates were proposed: complete RPE and outer retinal atrophy (cRORA), incomplete RPE and outer retinal atrophy, complete outer retinal atrophy, and incomplete ...

2019年3月22日 · Areas of absent autofluorescence signal (787 nm) indicate complete retinal pigment epithelium (RPE) and outer retinal atrophy (cRORA). Yellow line crosses an area of mottled autofluorescence shown on histologic analysis.

development of complete RPE and outer retinal atrophy (cRORA) in age-related macular degeneration (AMD). We provide descriptive OCT and histologic examples of disease progression.

The mean baseline RPE atrophy area ranged from 4.74 to 11.52 mm 2, with a mean growth rate ranging from 1.24 to 2.42 mm 2 /y during a 1 to 1.5-year follow-up. The overall mean RPE-atrophy growth rate was 1.76 mm 2 /y (95% CI: 1.56-1.97; Figure 4) with a heterogeneity of I 2 = 67.57% between studies.

2022年12月23日 · Complete RPE and outer retinal atrophy (cRORA) succeeds incomplete RPE and outer retinal atrophy (iRORA) and defines the end stage in the evolution of atrophic lesions. To differentiate between iRORA and cRORA, atrophic lesions must fulfill a triumvirate of characteristics on OCT imaging: RPE loss (RPEL) and choroidal hypertransmission over 250 ...

2021年2月17日 · Complete RPE and outer retinal atrophy was defined by the following criteria: (1) a region of choroidal hypertransmission of 250 μm or more in diameter; and (2) a zone of attenuation or disruption of the RPE of 250 μm or more in diameter; and (3) evidence of overlying photoreceptor degeneration, all occurring in the absence of signs of an RPE ...