Phosphatidylinositol (PI), also known as inositol phospholipid, is a lipid composed of a phosphate group, two fatty acid chains, and one inositol molecule. It belongs to the class of phosphatidylglycerides and is typically found as a minor component on the cytosolic side of eukaryotic cell membranes.

Phosphatidylinositol is now known to be phosphorylated by substrate-selective kinases that place the phosphate moiety on positions 3, 4 and/or 5 of inositol with the balance among them maintained by phosphatases and phospholipases.

2022年5月19日 · Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous phospholipid in the cytoplasmic leaflet of eukaryotic membranes.

Phosphatidylinositol refers to a molecule that plays multiple roles in biology, including modulating the function of membrane proteins. It is characterized by the presence of inositol in its headgroup and can undergo phosphorylation on the sugar hydroxyls.

Phosphatidylinositol is the parent lipid for the synthesis of seven phosphorylated inositol lipids and each of them play specific roles in numerous processes including receptor-mediated signalling, actin cytoskeleton dynamics and membrane trafficking.

Phosphatidylinositol (PI) is a lipid that is formed in the ER by the CDP-dependent PI exchange protein that catalyzes the attachment of inositol phosphate onto diacylglycerol (see Chapter 4; Sandelius and Morré, 1987). Inositol lipids are enriched in the cytosolic leaflets of membranes.

Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have emerged as regulators of key sub-cellular processes such as membrane transport, cytoskeletal function and plasma membrane signaling in eukaryotic cells.

PPIs ( polyphosphoinositides) are reversibly phosphorylated derivatives of the membrane phospholipid phosphatidylinositol (PI, Figure 1A). They are low-abundance lipids of the cytoplasmic leaflet of all eukaryotic cellular membranes.

Phosphatidylinositol 4,5 bisphosphate [PI (4,5)P 2] is the most abundant of the phosphoinositides, the phosphorylated derivatives of phosphatidylinositol (PI) that regulate numerous sub-cellular processes in eukaryotic cells [1].

2015年10月16日 · In eukaryotes, phosphatidylinositol (PI)-based lipids (phosphoinositides) play important roles in numerous aspects of intracellular signalling and in the anchoring of...