Neurofibroma is a benign nerve sheath tumorarising in the peripheral nervous system. It may be sporadic or associated with Neurofibromatosis 1. Based on the growth pattern, it is subdivided into localized, plexiform, and diffuse types.

Neurofibroma is an uncommon skin lesion in the peripheral nerve sheath tumour grouping. This article also includes plexiform neurofibroma.

2023年8月8日 · Neurofibromas are the most common peripheral nerve sheath tumor and are often found either by patients or during routine skin exams. These lesions appear as soft, skin-colored papules or small subcutaneous nodules. There are three main types of neurofibromas: localized, diffuse, and plexiform.

In a neurofibroma, sections show a non- encapsulated lesion in the dermis (figure 1). These lesions represent a proliferation of all elements of peripheral nerves. The cells have wavy serpentine nuclei and pointed ends (figures 2-4). There is stromal mucin deposition and fibroplasia (figures 2-4).

In this review we discuss current concepts and problematic areas in the pathology of peripheral nerve sheath tumors. Diagnostic criteria and differential diagnosis for the major categories of nerve sheath tumors are proposed, including neurofibroma, schwannoma, and perineurioma.

Neurofibromas are benign peripheral nerve sheath tumors mainly composed of neoplastic cells showing schwannian differentiation admixed to a minor component of cells with fibroblastic and perineurial differentiation.

2021年6月22日 · Neurofibromas are benign peripheral nerve sheath tumors most commonly associated with neurofibromatosis. The condition usually presents in patients with neurofibromatosis with cutaneous lesions, as well as lesions near the …

2020年2月14日 · Three major types exist: localized (cutaneous or intraneural), diffuse, and plexiform, the latter being pathognomonic for neurofibromatosis type I (NF1). Neurofibromas are the most common peripheral nerve sheath tumors. …