A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.

2023年8月8日 · From the sinusoids, the blood drains into the central vein, which occupies the central axis of the classic liver lobule. The endothelial cells forming the central veins are surrounded by a small quantity of connective tissue fibers.

Liver sinusoids are thought to be the main site of blood flow regulation within the liver. LSECs respond to changes in portal blood flow and pressure, and even produce vasoactive molecules to signal to HSCs and eventually regulate the sinusoidal diameter.

2018年8月8日 · Liver sinusoids are a type of fenestrated/porous blood vessel which compose the 'capillary bed' of the liver parenchyma. They receive terminal branches of the oxygen-rich hepatic artery (terminal hepatic arterioles) and nutrient-rich portal vein (terminal portal venules).

The unique characteristics of sinusoids and sinusoidal cells in the normal liver explain their major role in facilitating exchange between blood and hepatocytes, in intercellular communication and in ECM deposition, inflammation and liver immunity.

A sinusoid is a form of blood channel usually described as a large, irregular capillary, having a discontinuous lining of endothelium, with little or no adventitia; sinusoids are found in the liver, spleen, and bone marrow (Dorland, 2011).

The liver sinusoids. Blood enters the liver at the portal tracts, passes through a network of sinusoids and leaves the liver via the hepatic central vein. The liver sinusoids are lined by a fenestrated layer of liver sinusoidal endothelial cells (LSEC).