Inflammatory pathways impact the pathogenesis of a number of chronic diseases, and involve common inflammatory mediators and regulatory pathways. Inflammatory stimuli activate intracellular signaling pathways that then activate production of inflammatory mediators.

2021年8月21日 · The inflammatory responses is a controlled, co-ordinated stimulation of signaling pathways regulating the levels of mediators involved in inflammation at the tissue site and recruiting inflammatory cells from blood to maintain tissue homeostasis (Lawrence, 2009).

The resolution of inflammation is an active process that enables inflammation to switch off, protecting tissue from persistent injury and restoring tissue homeostasis. Like inflammation, resolution involves several mediators and signaling pathways that control immune cell functions.

The inflammatory response has four phases: inflammatory inducers (infection or tissue damage), inflammatory sensors (mast cells and macrophages), inflammatory mediators (cytokines, chemokines, etc.) and the tissues that are affected [3].

A growing number of researchers have discovered various signaling pathways that are associated with the initiation and progression of inflammation. Among different pathways, we will focus on three classical inflammatory pathways: p38 MAPK, IL-6/JAK/STAT3 and PI3K; and a non-classical inflammatory pathway, the Hippo.

2017年7月19日 · Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

2024年6月8日 · The inflammatory pathway involves inducers, sensors, mediators, and effectors. Inducers initiate the inflammatory process, including infectious organisms or noninfectious stimuli such as foreign bodies and signals from damaged tissues or necrotic cells.

4 天之前 · A normal inflammatory response requires a balance between pro- and anti-inflammatory signals. Such a response can be achieved by competition between the precursors of bioactive metabolites. Macrophages can produce arachidonic acid, a precursor to proinflammatory molecules, and eicosapentaenoic acid, a molecule that inhibits inflammation.

2021年11月25日 · Recent advances have uncovered a broad range of biological processes that involve inflammatory control, calling for a renewed framework of inflammation beyond its classical roles in defense from infection and injury.

2017年12月14日 · Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.