Epoxide Hydrolase, a Fat New Target for Alzheimer’s Therapy?
2020年12月15日 · The scientists found more epoxide hydrolase in brain tissue from people with AD and 5xFAD mice than in controls, corresponding to fewer epoxy fatty acids in the mice. …
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ ...
2023年8月2日 · Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease. Neurotherapeutics. 2020 Jun 2; PubMed. Martini RP, Siler D, Cetas J, …
Soluble epoxide hydrolase: a next-generation drug target for …
Soluble epoxide hydrolase: a next-generation drug target for Alzheimer's disease and related dementias. Neural Regen Res. 2025 Sep 1;20(9):2585-2586. Epub 2024 Sep 6 PubMed. …
Could Inhibiting a Liver Enzyme Ameliorate Alzheimer’s
2023年8月2日 · But what if targeting a peripheral enzyme could do the job? In the June 26 Neuron online, researchers led by Xin-Hong Zhu at Shenzhen University, China, reported that …
Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its ...
Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment. Free …
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer ...
Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease. PLoS One. 2012;7(6):e39186. PubMed. Recommends. Please login to recommend the paper. Comments. …
TMEM175 Maintains Lysosome pH by Pushing Out Protons
2022年6月23日 · The work of this paper and others suggests that the function of each of the proteins encoded by these genes are intimately connected. For instance, glucocerebrosidase …
Genetic deletion of soluble epoxide hydrolase delays the …
Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease. J Neuroinflammation. 2019 Dec 17;16(1):267. PubMed. Recommends. Please login to …
APOE Christchurch-mimetic therapeutic antibody reduces APOE …
2023年10月30日 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and …
New Therapeutic Strategy—Mimic the ApoE Christchurch Mutation?
2023年10月24日 · Further, a recent study showed that inhibition of liver enzyme soluble epoxide hydrolase drives a subsequent increase of 14,15-epoxyeicosatrienoic acid in the blood and …