Here we provide an overview of the current understanding of B cell development and function and briefly describe inborn errors of immunity associated with B cell development defects which can manifest as immune deficiency, malignancy, autoimmunity, or allergy.

Most of our understanding of fetal B-lymphopoiesis has been based on murine data, but many recent studies have focussed on characterizing human fetal B-cell development, including functional and molecular assays at a single cell level.

Immature B cells continuously develop from hematopoietic stem cells, in a process guided by an intricate network of transcription factors as well as chemokine and cytokine signals. Humans and mice possess somewhat similar regulatory mechanisms of B lymphopoiesis.

Since the identification of B cells in 1965 (Cooper et al. 1965), three has been tremendous progress in our understanding of B cell development, maturation and function. A number of B cell subpopulations, including B-1, B-2 and regulatory B cells, have been identified.

B-cell development. The figure shows the broad outline of B-cell developmental stages in mice and humans. B-1a, B-1b, and B10 populations are less well characterized in humans. CLP indicates common lymphoid progenitor; SHM, somatic hypermutation; and CSR, class switch recombination. Illustration by A. Y. Chen.

2022年8月11日 · The development of B cells in a normal human body goes through seven important stages. Each stage is characterized by several activities that make it unique and something that scientists can map in the laboratory.

Human B cell development consists of a series of cellular transitions that begins in fetal liver or marrow with the development of lymphoid cells from HSCs and culminates in the seeding of secondary lymphoid tissue with antigen-specific naïve B cells.

see how B cell development results in B cell diversity and allotypic exclusion. understand what regulates the development of B cell specificity. learn about different functional classes of B cells and their distribution in the body. test your knowledge and immunology problem-solving skills. Generation of B Cells.

2014年3月16日 · In this review we summarize recent insights into the development of human B cells primarily by studying immunodeficiencies. Development and differentiation of B cells can be considered as a paradigm for many other developmental processes in cell biology.

2023年9月1日 · Deeper understanding of signals and regulation of human early B cell development enables the prediction of potential adverse events from targeted therapies and paves the way for the identification of new targets to modulate development.