Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes.

2010年10月11日 · Homeobox gene interactions become exponentially complex as the multidimensional nature of gene regulatory networks is explored. However, it has given rise to an entirely new perspective on developmental biology and molecular genomics.

1997年10月1日 · Homeobox genes are master developmental control genes that act at the top of genetic hierarchies regulating aspects of morphogenesis and cell differentiation in animals. These genes...

Homeobox genes are characterized by a conserved 180-bp DNA sequence coding for a 60-aminoacid DNA-binding domain called the ‘homeodomain’. They function as transcription factors recognizing specific DNA sequences and regulate target genes (McGinnis and Krumlauf, 1992; Quiring et al., 1994).

2022年5月14日 · Antp and Ubx are two of 8 homeobox genes that are linked in a cluster on one Drosophila chromosome. All of them encode transcription factors, each with a DNA-binding homeodomain and act in sequential zones of the embryo …

2020年3月16日 · Homeobox genes are a group of genes that regulate development in multicellular organisms; this includes cell differentiation and morphogenesis. They were first discovered in the fruit fly...

Homeobox refers to a conserved DNA sequence responsible for encoding a 60-amino acid protein motif called the homeodomain. This domain functions as a helix-turn-helix DNA-binding motif, allowing homeobox genes to act as transcription factors in various developmental processes across different organisms.

We describe 300 human homeobox loci, which we divide into 235 probable functional genes and 65 probable pseudogenes. These totals include 3 genes with partial homeoboxes and 13 pseudogenes that lack homeoboxes but are clearly derived from homeobox genes.

2024年3月18日 · This year, 2024, marks the 40th year of the discovery of the homeobox, a landmark discovery that fundamentally impacted multiple fields, ranging from genetics and genomics to developmental biology, neuroscience and evolution.

2018年6月21日 · Homeobox genes are a group of similar genes having a common DNA sequence (a homeobox) responsible for coding a homeodomain. They play a vital role in governing the formation of bodily segmentation and cell …