2023年11月14日 · In this study, we examined the levels of EZH2 protein and H3K27me3 shortly after CTX or its active metabolite 4-hydroperoxy cyclophosphamide (4-HC) treatment to investigate the role of EZH2...

2021年1月29日 · PcG domains are marked by H3K27me3, which is deposited by the catalytic component of PRC2 complex, mainly Enhancer of Zeste Homolog 2 (EZH2) and sometimes EZH1 20. H3K27me3 marks are...

2024年2月21日 · EZH2 is a histone modifier that is frequently detected to be abnormal in cancers and alters the entire epigenome by increasing H3K27me3 levels. Targeting EZH2 provides a therapeutic benefit...

The core subunits contribute to the establishment and maintenance of H3K27me3: EZH2 utilizes SAM as the metabolic substrate for histone methylation; SUZ12 promotes the EED-EZH2 complex formation and the recruitment of PRC2 compositions; EED …

2008年11月21日 · Depletion of Ezh1 in cells lacking Ezh2 abolishes residual methylation on H3K27 and derepresses H3K27me3 target genes, demonstrating a role of EZH1 in safeguarding ESC identity. Ezh1 partially complements Ezh2 in executing pluripotency during ESC differentiation, suggesting that cell-fate transitions require epigenetic specificity.

Peeters et al. demonstrate that increasing H3K27me3 levels in regulatory T (Treg) cells by hyperactivating the H3K27me3 methyltransferase EZH2 pushes naive Treg cells toward a CD28-activated state. This promotes Treg cell migration to tissues for …

2023年3月21日 · Regulation of the Wnt/β-catenin linked protein pathway by EZH2 was found to depend on trimethylation enrichment at position 27 of lysine in histone H3 (H3K27me3) in the promoter region, thereby reducing apoptosis and inflammation.

2020年2月10日 · Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clinical trials, EZH2 inhibitors are currently tested to overcome resistance to ICB.

2023年11月27日 · Mechanistically, EZH2 promotes TOP2A expression by regulating the H3K27me3-mediated epigenetic silencing of miR-139-5p. TOP2A is a direct target of miR-139-5p, and inhibition of miR-139-5p can reverse the promotion by EZH2 of TOP2A expression.

EZH2 catalyzes the trimethylation of histone 3 lysine 27 (H3K27me3), leading to the repression of gene transcription and regulating proliferation and differentiation in the growth process (Barsotti et al., 2015).