Glycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in …

2024年8月5日 · Glycosylation is crucial in regulating protein stability. Glycosylation can enhance the stability and solubility of proteins, thereby improving their half-life and drug properties in vivo.

2021年6月28日 · Glycosylation is an essential biochemical process. It promotes proper protein folding and produces complex molecules that carry out regulatory functions. Glycosylation is …

2020年10月21日 · Glycosylation is the most abundant and diverse form of post-translational modification of proteins that is common to all eukaryotic cells.

2019年3月11日 · We review how glycosylation patterns are altered in multiple human diseases, including congenital disorders of glycosylation (CDGs) as well as autoimmune, infectious and …

2024年8月5日 · A growing body of evidence suggests that glycosylation is essential for the unfolding of various functional activities in organisms, such as playing a key role in the …

This chapter provides an overview of glycosylation from the perspective of a single cell, taking into account the patterns of expression, topology, and other features of the biosynthetic and …

Major advances in quantitative transcriptomics, proteomics and nuclease-based gene editing are now opening new global ways to explore protein glycosylation through analysing and targeting …

2019年4月1日 · Protein glycosylation is the covalent attachment of single sugars or glycans, i.e., multi-sugar polysaccharides or complex oligosaccharides, to select residues of target proteins.

2024年10月21日 · Glycosylation is a post-translational modification that influences numerous cellular processes and overall health. This biochemical process involves the attachment of …