The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximately 10 μg/ml. Endogenous respiration was unaffected by ...

2022年4月1日 · Farmakologi miconazole sama seperti antifungal golongan azole lainnya, yaitu sebagai fungistatik dalam inhibisi sintesis komponen dinding sel. Miconazole dimetabolisme di hati dan dapat ditemukan pada feses

The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximatel...

Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. 3 It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are ...

In vitro, miconazole effectively inhibits placental and fetal adrenal steroid aromatase. Miconazole is absorbed systemically after vaginal application, reaching peak levels approximating 10ng/ml. In contrast, parenteral levels of miconazole exceed mcg/ml. Post-marketing studies are reassuring, revealing no excess rates of adverse outcomes.

Miconazole is a member of a class of imidazole agents that elicit broad-spectrum antifungal activity. A novel solid-phase iodoetherification reaction was employed in the solid-phase synthesis of 45 miconazole analogs.

Apa itu Miconazole? Miconazole adalah obat yang digunakan sebagai antijamur yang menyerang berbagai organ tubuh seperti mulut, kulit, hingga vagina. Obat ini umumnya dijual sebagai obat topikal berupa miconazole nitrate dalam kemasan salep maupun krim.

farmakologi / mekanisme aksi miconazole Inhibisi biosintesis ergosterol, merusak membran dinding sel jamur yang selanjutnya akan meningkatkan permeabilitas, sehingga menyebabkan hilangnya nutrisi sel.

2022年4月1日 · Miconazole merupakan obat antifungal golongan azole yang dapat digunakan dalam penatalaksanaan infeksi berbagai jenis fungi seperti kandidiasis, coccidiodomycosis, cryptococcosis, paracoccidioidomycosis, dan infeksi Pseudeliescheria boydii.

Introduction: Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes.