Fibronectin is a high-molecular weight (~500-~600 kDa) [5] glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. [6] Fibronectin also binds …

Fibronectin is formed by the joining of two similar polypeptide subunits via a pair of disulfide bonds near the C-terminal of each (Figure \(\PageIndex{5}\)). Each subunit is arranged as a linear …

2002年10月15日 · Fibronectin (FN) mediates a wide variety of cellular interactions with the extracellular matrix (ECM) and plays important roles in cell adhesion,migration, growth and …

2006年10月10日 · One essential component of the ECM is the protein fibronectin that assembles into fibrils attaching cells to the ECM. Besides the fibrillar form, fibronectin also has a compact …

2018年1月1日 · Fibronectin is probably best known for its ability to promote cell adhesion and, under many conditions, cell motility. Cells cultured on fibronectin typically spread and form …

2011年9月16日 · Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles during tissue repair. The plasma form of FN circulates in the blood, and upon …

2021年9月16日 · The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of cell signal transduction in tissues. In times of ECM assembly and turnover, cells …

2017年1月1日 · Fibronectin is implicated in a variety of different biological phenomena such as cell adhesion via its receptors (Fig. 2) and the establishment and maintenance of normal cell …

Fibronectin (FN) is involved in many cellular processes, including tissue repair, embryogenesis, blood clotting, and cell migration/adhesion. Fibronectin exists in two main forms: 1) as an …

Fibronectin (FN) is a multifunctional, extracellular matrix glycoprotein composed of two nearly identical disulfide bound polypeptides of molecular weight 220 kDa. Cellular fibronectin is …