Endocardial fibroelastosis (EFE) signifies the pathological process by which collagen and elastin are focally or diffuse deposited in the endocardium of the left ventricle. The new layer causes left ventricular dysfunction sometimes with fulminant ...

Histopathology The endocardium is a transparent thin layer approximately 10 micrometers in thickness consisting of only 5 layers. [11] Histopathological findings in samples from the autopsies have shown thickening of all five layers, and an increase in elastin and collagen fibers deposition. [20]

A clinical and pathologic study of 47 cases with endocardial fibroelastosis is presented. These cases have been classified according to the associated cardiac anomaly and the anatomic condition of the left ventricle.

Fibroelastosis of the endocardium is a congenital condition of unknown cause in which there occurs a diffuse thickening of the mural endocardium associated in most cases with myocardial hypertrophy, and leading to early death.

Endocardial fibroelastosis (EFE) refers to the thickening of the ventricular endocardium as a result of de novo deposition of subendocardial fibrous tissue layers during neonatal heart...