Excitotoxicity may be involved in cancers, spinal cord injury, stroke, traumatic brain injury, hearing loss (through noise overexposure or ototoxicity), and in neurodegenerative diseases of the …

Excitotoxicity is a hyperacute secondary injury mechanism that initiates shortly after a brain insult. It is characterized by pathologically high levels of excitatory neurotransmitters such as …

Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such …

兴奋性毒性 (Excitotoxicity) 是一种神经细胞损伤的生物学现象，主要由于神经元受到过多的兴奋性神经递质的刺激而引起。 这一概念最早由Olney等人于1969年首次提出，并在此后的研究中得 …

2009年4月3日 · This review discusses the current understanding of excitotoxic mechanisms and how they are involved in the pathogenesis of neurodegenerative diseases.

In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a …

Excitotoxicity refers to an excessive activation of neuronal amino acid receptors. The specific type of excitotoxicity triggered by the amino acid glutamate is the key mechanism implicated in the …

A better understanding of the excitotoxic process is not only leading to the development of novel therapeutic approaches for neurodegenerative disorders, but also to unexpected insight into …

Over the next two decades, the subfield of excitotoxicity likewise expanded, driven most prominently by its implication in the pathogenesis of ischemic brain damage, and several …

Excitotoxicity is mediated by excessive calcium influx and release from internal organelles, oxyradical production and the activation of a form of programmed cell death called apoptosis.