Endothelin functions through activation of two G protein-coupled receptors, endothelin A and endothelin B receptor (ETA and ETB, respectively). [2] These two subtypes of endothelin receptor are distinguished in the laboratory by the order of their affinity for the three endothelin peptides: the ETA receptor is selective for ET-1, whereas the ...

2023年5月1日 · Endothelin is a 21-amino acid long peptide that is a vasoconstrictor produced from endothelial cells, vascular smooth muscle cells (VSMC), macrophages, and the renal medulla. They are known to produce endothelin-1 (ET-1) that acts on the receptors ETA and ETB.

Endothelin (ET) is a peptide (small protein) that helps regulate your blood pressure by constricting (tightening) your blood vessels. Peptides are small proteins made up of short chains of amino acids (organic compounds).

Endothelin (ET-1) is a 21 amino acid peptide that is produced by the vascular endothelium from a 39 amino acid precursor, big ET-1, through the actions of an endothelin converting enzyme (ECE) found on the endothelial cell membrane.

Endothelin was first discovered more than 30 years ago as a potent vasoconstrictor. In subsequent years, three isoforms, two canonical receptors, and two converting enzymes were identified, and their basic functions were elucidated by numerous preclinical and clinical studies.

The Research on Endothelin Antagonism in Chronic Heart failure (REACH-1) trial with bosentan was terminated early because of hepatic side effects. The results showed an early worsening (at 3 months) and a potential benefit at 6 months, with decreased symptoms …

2019年11月4日 · Discovered in 1987 as a potent endothelial cell–derived vasoconstrictor peptide, endothelin-1 (ET-1), the predominant member of the endothelin peptide family, is now recognized as a multifunctional...

Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was originally isolated and characterized from the culture media of aortic endothelial cells. Two other isoforms, termed endothelin-2 and endothelin-3, were ...

1995年6月1日 · In human essential hypertension, there is some evidence of activation of the endothelin system despite depressed responses of small arteries to endothelin-1 and normal circulating levels of endothelin-1 in plasma.

Here, we summarize the main clinical trials using ERAs and discuss the role of endothelin in cardiovascular diseases such as arterial hypertension, preecclampsia, coronary atherosclerosis, myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) caused by spontaneous coronary artery dissection (SCAD), Takotsubo ...