Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. [2]

2023年8月8日 · Cytarabine is a pyrimidine analog and is also known as arabinosylcytosine (ARA-C). It is converted into the triphosphate form within the cell and competes with cytidine to incorporate itself into the DNA. The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA.

2024年11月25日 · Cytarabine is used together with other cancer drugs to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat or prevent leukemia associated with meningitis. Cytarabine will not treat a meningitis infection. Cytarabine may also be used for purposes not listed in this medication guide.

Cytarabine (cytosine arabinoside; Ara-C) in multiagent chemotherapy regimens is often used for leukemia or lymphoma treatments, as well as neoplastic meningitis. Chemotherapy regimens can induce a suboptimal clinical outcome in a fraction of patients.

It is also known as Ara C or cytosine arabinoside. You pronounce cytarabine sye-ta-ra-bin. It is a treatment for: How does cytarabine work? Cytarabine is a type of chemotherapy drug called an anti metabolite . It kills cancer cells by stopping them from making and repairing DNA that they need to grow and multiply. How do you have cytarabine?

Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate). This metabolite then damages DNA by multiple mechanisms, including the inhibition of alpha-DNA polymerase, inhibition of DNA repair through an effect on beta-DNA polymerase, and incorporation into DNA.

Cytarabine is FDA approved to prevent and treat leukemia that has spread to the meninges (the three membranes that cover the brain and spinal cord). It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic …

Cytarabine (formerly cytosine arabinoside), an inhibitor of DNA synthesis, is primarily used in the treatment of leukemia. Patients with cytarabine-induced lung injury typically present with fever, cough, dyspnea, hypoxia, and evidence of pulmonary edema.

2017年11月3日 · Cytarabine (sye tar' a been) is an nucleoside analogue (cytosine arabinoside: ara-C) which is converted intracellularly to a triphosphate, which competes with cytosine triphosphate for incorporation into RNA and DNA and acts as an inhibitor of RNA and DNA polymerase, thus blocking DNA synthesis and cell division.

The antimetabolite cytosine arabinoside (ara-C) represents a prototype of the nucleoside analog class of antineoplastic agents and remains one of the most effective drugs used in the treatment of acute leukemia as well as other hematopoietic malignancies.