Chondrogenesis is the biological process through which cartilage tissue is formed and developed. This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skeleton.

Chondrogenesis occurs as a result of condensation of mesenchymal cells, which express collagens I, III and V, and chondroprogenitor cell differentiation with expression of cartilage-specific collagens II, IX, and XI.

Chondrogenesis is a critical process in the development and healthy maintenance of the vertebrate skeleton [1]. It consists in generating chondrocytes and in directing these cells through successive steps of commitment and differentiation in order to build, renew or remodel cartilage tissues in a tightly controlled spatial and temporal manner.

Chondrogenesis is a dynamic process involving mesenchymal stem cell recruitment, migration, condensation of progenitor cells, chondrocyte differentiation, proliferation, hypertrophy, and angiogenesis. Types of fibrocartilage: Intra-articular, connecting, stratiform, circumferential.

2021年3月22日 · Successful chondrogenesis was confirmed by increased expression of chondrogenic markers such as MATN4, ACAN, COL2A1, COL6A3, COL9A1, SOX6 and SOX9. Bulk RNA-seq data also revealed that hiPSC ...

Chondrogenesis, the initial development of skeletal bones, starts during embryonic development in the early stages of somitogenesis and is considered to be the earliest phase of skeletal development. It involves progenitor cell specification, cell migration, epithelial-to-mesenchymal transition, and differentiation and maturation of chondrocytes.

Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal cells (MSC) are complex and highly regulated processes. Over the years, several studies have focused on understanding the mechanisms involved in the MSC commitment to the osteogenic, adipogenic and/or chondrogenic phenotypes.

This chapter will focus on the methods involved in the isolation and expansion of human mesenchymal stem cells, their differentiation along the chondrogenic lineage, and the qualitative and quantitative assessment of chondrogenic differentiation.

2021年5月27日 · Chondrocytes are the only cell type (accounting for 1%) in cartilage tissue and secrete growth factors and enzymes to regulate extracellular matrix (ECM) synthesis. They further embed themselves in ECM to form cartilage (Jiang and Tuan, 2014).

2024年3月19日 · Chondrogenesis is a process of cartilage development in which mesenchymal cells express collagen I, III and V. The initial site of cartilage formation is an aggregation of mesenchymal cells known as the chondrogenic nodule. Transcription factor then triggers the differentiation of these cells into chondroblasts.