Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. [a] Its main current use in pharmacology is treating molluscum contagiosum and warts topically. [2] . It is a burn agent and poisonous in large doses, and has been historically used as aphrodisiacs (Spanish fly).

Cantharides, or cantharidin, consists of the broken dried remains of the blister beetle (q.v.) Lytta vesicatoria. It has been a traditional sexual stimulant fed to male livestock to facilitate…

Cantharidin is a vesicant that causes a blister to form on the wart or growth. This action lifts the wart off the skin and after a few days when the blister has dried the wart will come off. The action of cantharidin does not go beyond the epidermal cells, the …

Cantharidin is a monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A. It has a role as an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor and a herbicide.

2016年10月20日 · Cantharidin is a natural toxin produced by the blistering beetle that possesses both vesicant (blistering) and keratolytic effects. 1, 2 The substance elicits these effects by inducing acantholysis (loss of intercellular connections) through the targeting of the desmosomal dense plaque, resulting in the detachment of the desmosomes from the tono...

Lytta vesicatoria, also known as the Spanish fly, is an aposematic emerald-green beetle in the blister beetle family (Meloidae). It is distributed across Eurasia. The species and others in its family were used in traditional apothecary preparations as "Cantharides".

2024年5月15日 · Cantharidin, a monoterpene anhydride (molecular formula C10H12O4), is one of the better-known toxins produced by a group of insects (Fig. 1 B) (Eisner et al. 1990). The autogenous producers of this chemical occur exclusively within the coleopteran families of Meloidae (true blister beetles) and Oedemeridae (false blister beetles).

Cantharidin is a toxic vesicant found in blister beetles, causing severe irritation to the skin, mucous membranes, and urinary tract. It is known for its potent vesicant properties and is believed to inhibit specific protein phosphatases, leading to toxicity. You might find these chapters and articles relevant to this topic. C.R. Wilson, ...

Southern and Central Europe, mainly on plants of the family Oleaceae and Caprifoliaceae. Constit. 0.6-1% cantharidin, q.v., 10-15% fat, resinous substances, acetic and uric acids. Review: Ude, Heeger, Pharm. Zentralhalle 82, 193 (1941); A. Kar, Pharmacognosy and Pharmacobiotechnology (New Age Intl., New Delhi, 2003) pp 199-200.

2020年11月1日 · Norcantharidin (NCTD) is a structural modifier of CTD. To compare with CTD, NCTD has lighter side effects and stronger bioactivity in anti-cancer through inhibiting cell proliferation, causing apoptosis and autophagy, overwhelming migration and metastasis, affecting immunity as well as lymphangiogenesis.