2024年12月24日 · CYP11B2 (Cytochrome P450 Family 11 Subfamily B Member 2) is a Protein Coding gene. Diseases associated with CYP11B2 include Corticosterone Methyloxidase Type Ii Deficiency and Corticosterone Methyloxidase Type I Deficiency .

Angiotensin II or potassium regulates the aldosterone synthase gene, CYP11B2. The adrenocorticotropic hormone controls the 11b-hydroxylase, CYP11B1. DNA methylation negatively controls the CYP11B2 and CYP11B1 expression and dynamically changes the expression responsive to continuous stimulation of the promoter gene.

The CYP11B2 gene provides instructions for making an enzyme called aldosterone synthase (previously known as corticosterone methyloxidase). Learn about this gene and related health conditions.

The CYP11B2 enzyme is the terminal enzyme in the biosynthesis of aldosterone. Immunohistochemistry using antibodies against CYP11B2 defines cells of the adrenal ZG that synthesize aldosterone. CYP11B2 expression is normally stimulated by angiotensin ...

CYP11B2 polymorphism is an independent predictor for atrial fibrillation development in hypertrophic cardiomyopathy patients. CYP11B2 genotype were associated to type 2 diabetes mellitus. Heterogenous immunolocalization of CYP11B2 and diffuse immunoreactivity of CYP11B1 were detected.

2023年12月1日 · Aldosterone synthase (CYP11B2) represents a promising drug target because its genetic dysregulation is causally associated with cardiovascular disease, its autonomous activity leads to primary aldosteronism, and its deficiency leads to salt wasting syndromes.

Aldosterone synthase (CYP11B2) deficiency is a rare autosomal recessive disorder, usually presenting with severe salt-wasting in infancy or stress-induced hyperkalaemia and postural hypotension in adulthood.

2024年11月2日 · Clinical resource with information about CYP11B2, Corticosterone 18-monooxygenase deficiency, Corticosterone methyloxidase type 2 deficiency, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

1998年2月17日 · Such variations might be associated with polymorphisms in the gene encoding aldosterone synthase (CYP11B2), the enzyme catalyzing the last steps of aldosterone biosynthesis.

Human CYP11B2 shows a high sequence identity of approximately 93% to 11β-hydroxylase (CYP11B1), an enzyme that is critical for the synthesis of cortisol and is mainly present in the zona fasciculata/reticularis.11 A further considerable obstacle to the development and pharmacody-namic characterization of selective CYP11B2 inhibitors is encounter...