2023年1月17日 · A CD8 count (cytotoxic T cells) between 150 to 1,000 cells per cubic millimeter is considered normal. Your healthcare provider can explain what a normal result looks like for you depending on your condition and general health.

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell-antigen interactions.

CD8 + T cells are recognized as T C cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system. However, CD8 + T cells also have the ability to make some cytokines, such as TNF-α and IFN-γ, with antitumour and antimicrobial effects.

Here we review recent advances in CD8 + T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8 + T cell expansion and differentiation are controlled in these contexts.

2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and...

CD8+ T cells (often called cytotoxic T lymphocytes, or CTLs) are very important for immune defence against intracellular pathogens, including viruses and bacteria, and for tumour surveillance. When a CD8+ T cell recognises its antigen and becomes activated, it has three major mechanisms to kill infected or malignant cells.

In this article we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation and also highlight the potential counterbalancing role of IL-21.

2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.

2024年10月10日 · The CD8 coreceptor is an integral component of the cytotoxic T cell, distinguishing itself by its affinity for major histocompatibility complex (MHC) class I molecules. This interaction is pivotal in the immune system’s ability to target and eliminate infected or malignant cells.

2025年1月15日 · Additionally, CD8+ T-cells can produce cytokines like IFN-γ and TNF-α, which further contribute to the immune response by enhancing the activity of other immune cells and inhibiting viral replication. The ability of CD8+ T-cells to form memory cells is another aspect of their functionality. These memory cells persist long-term, providing ...