CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell …

Learn about cytotoxic T cells, also referred to as CD8+ T cells, including cell activation, differentiation, and function in adaptive immune response.

2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer …

Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T cell …

Here we review recent advances in CD8 + T cell recognition of antigen in lymphoid as well as in nonlymphoid tissues in the periphery, and how CD8 + T cell expansion and differentiation are …

CD8+ T cells (often called cytotoxic T lymphocytes, or CTLs) are very important for immune defence against intracellular pathogens, including viruses and bacteria, and for tumour …

While CD8 is widely recognized as a co-stimulatory molecule for conventional CD8 + αβ T cells, recent reports highlight its multifaceted role in both adaptive and innate immune responses. In …

2021年5月12日 · CD8 + T cells contribute to organismal homeostasis. Cytolytic effector CD8 + T cells help to eliminate pathogens through cytokine secretion and direct killing of infected cells, …