Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). [5] Multiple transcript variants encoding …

CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor. A protein found on the surface of many different types of cells. It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow.

4 天之前 · CD117 is a proto-oncogene activated in GIST tumors, receptor for kit protein, a 145 kD tyrosine kinase growth factor receptor protein

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.

CD117, also known as c-kit, is a protein that acts as a receptor on the surface of specific cells in the body. It is involved in cell growth, survival, and development, particularly in cells that form part of the blood, skin, and digestive system.

CD117, also known as c-kit, is a tyrosine kinase receptor that is expressed in most hemopoietic stem and progenitor cells, as well as mast cells. It is a marker used for the detection of mast cell disorders and identification of myeloblasts in acute leukemias.

2024年12月25日 · KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with KIT include Piebald Trait and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by extracellular domain mutants of KIT.

CD117, encoded by the proto-oncogene c-kit, is a transmembrane protein belonging to the type III subfamily of the receptor tyrosine kinases . It has extracellular, intramembranous and intracellular domains.

2019年11月13日 · The CD117 (c-KIT) receptor tyrosine kinase is expressed on the cell surface of hematopoietic stem cells and its signaling is important in cell survival, proliferation and differentiation. CD117 is expressed in a majority of AML cases.

2019年2月6日 · Here we show that a single dose of a CD117-antibody-drug-conjugate (CD117-ADC) to saporin leads to > 99% depletion of host HSCs, enabling rapid and efficient donor hematopoietic cell...