Berbamine is a calcium channel blocker.

Berbamine | C37H40N2O6 | CID 275182 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Berbamine (1, Fig. 6.1, Scheme 6.6), a well-known bis-benzylisoquinoline alkaloid, is the major bioactive component isolated from traditional Chinese herbal medicines such as Berberis amurensis [152].

Berbamine, a bisbenzylisoquinoline alkaloid in medicinal plant Berberis amurensis, has shown anti-arrhythmic, anti-hypertensive and immunosuppressive activities. Moreover, massive work has been done on various forms of cancers including, breast cancer, myeloma, lymphoma and lung cancer ( Cheng et al., 2009 ).

Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate different oncogenic cell-signaling pathways in different cancers. In this review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers.

2020年9月18日 · Berbamine (BBM) is one of the major bioactive components of traditional Chinese herbal medicine Berberis amurensis. In Chinese medicine, there is a well-documented history of BBM being used in clinical practice for treating a variety of diseases, such as autoimmune disease, cancer, and inflammation.

Berbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine.

Berbamine, an alkaloid, attenuates the severity of EAE in mice by modulating STAT1 signaling (Ren et al., 2008). Further studies targeting STAT1 inhibition are required to be used as therapeutic in inflammatory disorders.

Our results suggest that berbamine is a novel inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. Multiple myeloma (MM) is the second most common hematological malignancy characterized by abnormal proliferation of plasma cells in bone marrow secreting monoclonal immunoglobulins.

2009年12月4日 · Our results suggest that berbamine is a novel inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. Multiple myeloma (MM) is the second most common hematological malignancy...