The basement membrane, also known as base membrane, is a thin, pliable sheet-like type of extracellular matrix that provides cell and tissue support and acts as a platform for complex signalling. [ 1 ] [ 2 ] The basement membrane sits between epithelial tissues including mesothelium and endothelium , and the underlying connective tissue.

2025年1月6日 · The basement membrane, also known as basal lamina, is a thin, dense layer of extracellular matrix that lines most human tissues forming the supporting structure and scaffolding for epithelial tissue and separates different types of cells, such as nerve cells and muscle cells.

2023年10月30日 · The basement membrane is a thin, non-cellular, extracellular protein matrix that forms a specialized supporting sheet directly beneath the basal surfaces of all epithelial cells, separating them from underlying supporting tissues.

Basement membranes provide an adhesive substrate for cells, and they are linked functionally to the actin cytoskeleton via integrins or other ECM receptors to mediate cell attachment and migration, as well as modulating intracellular signaling pathways.

Basement membranes (BMs) are present in every tissue of the human body. All epithelium and endothelium is in direct association with BMs. BMs are a composite of several large glycoproteins and form an organized scaffold to provide structural support to …

Basement membranes are widely distributed extracellular matrices that coat the basal aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells.

Basement membranes are thin sheet-like extracellular structures that form an anatomical barrier wherever cells meet connective tissues. They provide a substrate for organs and cells and relay important signals for the development of organs and for …

2017年3月20日 · Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were essential for the formation of tissues.

The basement membrane is the extracellular matrix (ECM) component of the BBB that consists of collagen IV, laminin, nidogen, and heparan sulfate proteoglycan 2 (perlecan), and agrin among others (Thomsen et al., 2017).

2003年6月1日 · Vascular basement membranes (BMs) are important structural and functional components of all blood vessels/capillaries and have a crucial role in determining the progression of cancer.