2021年3月16日 · Certain genes can increase the risk of developing dementia, including Alzheimer’s disease. One of the most significant genetic risk factors is a form of the apolipoprotein E gene called APOE4. About 25% of people carry one copy of APOE4, and 2 …

2024年8月21日 · The APOE gene test identifies the types of the APOE gene in your DNA. The APOE4 gene increases your risk of developing Alzheimer’s disease. The test results aren’t a diagnosis.

2024年6月7日 · The apolipoprotein E gene (APOE for short) is linked to Alzheimer’s risk because it's involved in the body’s process for carrying cholesterol and other fats in the bloodstream. People can have ...

2022年5月31日 · Researchers have discovered that a rare mutation inherited with the APOE4 gene variant protects against Alzheimer's, shedding new light on ways to counteract high-risk genes for the disease.

2024年9月12日 · A rare version of the fibronectin 1 gene may protect against Alzheimer’s in high-risk, APOE ε4 carriers, according to NIA-funded research.

Studies have long shown that if you carry two copies of the apolipoprotein E (APOE) 4 gene, your chances of developing Alzheimer’s disease are much higher. Now, researchers say in a new study...

2023年4月12日 · The APOE2 variant is the rarest form of APOE and is associated with a reduced risk for Alzheimer's. The APOE3 variant is the most common and has an average risk for Alzheimer's. The APOE4 variant, present in up to 15% of people, increases the risk for Alzheimer's disease.

2021年3月3日 · MIT researchers have found that the APOE4 gene, one of the most significant genetic risk factors for developing Alzheimer’s disease, has widespread effects on brain cells’ ability to metabolize lipids and respond to stress.

2017年10月24日 · Now researchers have connected ApoE4 to the toxic accumulation of another protein, tau, suggesting a possible new target for therapy. This work was published in Nature and supported by the National Institutes of Health (NIH).

The researchers found that the high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and other components that lines brain's blood vessels. Normally, this barrier allows nutrients into the brain and keeps harmful substances out.