In this review, we will summarize the findings on the molecular function of apoA-IV and apoA-IV-interacting proteins. The information will shed light on the discovery of apoA-IV receptors and the understanding of the molecular mechanism underlying its mode of action.

2024年12月24日 · APOA4 (Apolipoprotein A4) is a Protein Coding gene. Diseases associated with APOA4 include Apolipoprotein A-Iv Associated Amyloidosis and Familial Hyperlipidemia. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Familial hyperlipidemia type 1.

2015年8月1日 · ApoA-IV is primarily synthesized by the small intestine, attached to chylomicrons by enterocytes, and secreted into intestinal lymph during fat absorption. In circulation, apoA-IV is associated with HDL and chylomicron remnants, but a large portion is lipoprotein free.

The genes coding for three proteins of the plasma lipid transport system--apolipoproteins A1 (APOA1), C3 (APOC3), and A4 (APOA4)--are closely linked and tandemly organized on the long arm of human chromosome 11. In this study the human …

2024年12月9日 · Title: Autosomal dominant ApoA4 mutations present as tubulointerstitial kidney disease with medullary amyloidosis. Apolipoprotein A-IV of diabetic-foot patients upregulates tumor necrosis factor alpha expression in microfluidic arterial models.

Apolipoprotein A-IV (apoA-IV) is secreted by the small intestine on chylomicrons into intestinal lymph in response to fat absorption.

2023年11月23日 · Clinical resource with information about APOA4, A genome wide association study identifies common variants associated with lipid levels in the Chinese population., A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection., Biological, clinical and population relevance of 95 loci for blood lipids ...

2004年7月30日 · Apolipoprotein A-IV (apoA-IV) is an exchangeable apolipoprotein that shares many functional similarities with related apolipoproteins such as apoE and apoA-I but has also been implicated as a circulating satiety factor.

2019年4月5日 · In this review, we will summarize the findings on the molecular function of apoA-IV and apoA-IV-interacting proteins. The information will shed light on the discovery of apoA-IV receptors and the understanding of the molecular mechanism underlying its mode of action.

2019年4月5日 · In this review, we will first summarize our current understanding of APOA4 gene, apoA-IV protein structure, apoA-IV glycation, and apoA-IV isoforms. Second, we will discuss the cellular processes in which apoA-IV is likely involved and the signaling event it may trigger by focusing on lipoprotein metabolism, reverse cholesterol transport, anti ...