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    Nature
    https://www.nature.com › articles

    Rapid functionalization of multiple C–H bonds in unprotected …

    • The synthesis of valuable bioactive alicyclic amines containing variable substituents in multiple ring positions typically relies on multistep synthetic sequences that frequently require the introduction an… 展开

    Main

    The transformation of typically unreactive C–H bonds in feedstock alicyclic amines to C–C or C–X bonds provides a highly desirable entry to functionalized heterocycles1, w… 展开

    Nature
    Results and discussion

    Following considerable experimentation and optimization aimed at avoiding competitive and undesirable N-alkylation (Supplementary Table 1), conditions were identified that all… 展开

    Nature
    Data availability

    The data that support the findings of this study are available within the paper and its Supplementary Information. Crystallographic data for structures (±)-13a and (±)-13q hav… 展开

    Nature
    Acknowledgements

    Financial support from the NIH–NIGMS (grant no. R01GM101389) is gratefully acknowledged. We thank I. Ghiviriga (University of Florida) for assistance with NMR experiment… 展开

    Nature
    How are alicyclic amines synthesised?
    Nature Chemistry 12, 545–550 (2020) Cite this article The synthesis of valuable bioactive alicyclic amines containing variable substituents in multiple ring positions typically relies on multistep synthetic sequences that frequently require the introduction and subsequent removal of undesirable protecting groups.
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