17-Hydroxypregnenolone, S Useful For As an ancillary test for congenital adrenal hyperplasia (CAH), particularly in situations in which a diagnosis of both 21- and 11-hydroxylase deficiency have been ruled out

17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase that is present in the adrenal and gonads.

The 3-beta-HSD enzyme allows formation of 17-hydroxyprogesterone (17-OHPG) from 17-hydroxypregnenolone and progesterone from pregnenolone. When 3-beta-HSD is deficient, cortisol is decreased, 17-hydroxypregnenolone and pregnenolone levels may increase, and 17-OHPG and progesterone levels are low.

17-Hydroxypregnenolone is a steroid hormone produced within the body. The measurement of its levels in the blood serum provides valuable insights into hormonal balance and endocrine function.

17-Hydroxypregnenolone - 17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Steroidogenesis continues along two paths from pregnenolone. 17-Hydroxypregnenolone is produced from pregnenolone through the enzymatic action of 17-α-hydroxylase (17α-H). 3-β-hydroxysteroid dehydrogenase (3β-HSD) mediates the conversion of 17-hydroxypregnenolone to 17-hydroxyprogesterone.

17 Hydroxypregnenolone is a compound formed through the conversion of pregnenolone, essential for the production of cortisol and sex hormones. Deficiency in this process leads to decreased secretion of glucocorticoids and sex hormones, along with an increase in mineralocorticoids, resulting in hypertension and hypokalaemia.

17 Hydroxypregnenolone is a compound that is formed by the conversion of pregnenolone catalyzed by the enzyme Steroid 17α-hydroxylase (CYP17). It plays a role in the synthesis of dehydroepiandrosterone and is essential for androgen and estrogen biosynthesis. AI generated definition based on: Vitamins & Hormones, 1994

17-Alpha-Hydroxypregnenolone is an endogenous steroid hormone synthesized by the hydroxylation of pregnenolone, which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids, glucocorticoids, androgens, estrogens, and …

Analysis for 17-hydroxypregnenolone is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH.